During its long history more than twenty formulations of Coley Fluid were administered to patients. These formulations used different proportions of the bacterial ingredients and employed various methodologies to grow the bacteria and to sterilize the finished product. There were significant differences in potency between the various historical formulations and there were also variations in potency between batches of identical formulations.

The Company’s intellectual property (United States patent application 2006/0292173, published December 28, 2006) protects its proprietary methods of manufacturing MBVax Coley Fluid. These methods eliminate batch-to-batch variations and ensure equivalent potency to the best historical formulation of Coley Fluid